About the Longevity Testing Institute

Many products and health metrics in the longevity space sound questionable yet may truly help (or not). The Longevity Testing Institute connects companies, researchers, clinicians, and self-experimenters to evaluate longevity interventions and metrics; in order to discover and disclose what really works for long, healthy lives.

"Should I take this pill?" We will attribute:
  • a bronze medal for statistical evidence of whole-body (human or animal depending on the target of the product) health improvement, in the absence of severe condition other than aging
  • a silver medal for statistical evidence of long-term whole-body health benefits in a mammal (can be human), during at least a third of the typical lifespan in the second half of lifespan
  • a gold medal with either such long-term health statistics in people or a continuous surveillance to that end, when short-term effects align between animals and humans
Precisions & Q&A

The above is a simplification. Precisions with Q&A:

  • I am working on a gene therapy that wouldn't first be tried in people. Can't a mouse lifespan test suffice for a bronze medal? Yes, an alternative for bronze is to start with the silver conditions. Silver then also require the standard bronze conditions.
  • I am working on a new meditation approach. It can't be tested in animals. Is a silver medal not reachable in less than a few decades? In such a case, an alternative for silver is statistical health improvements over two years + a continuous long-term surveillance. This, to react would long-term deleterious effects be observed
  • I understand that N-of-1 trials are enough for badges. What about clinical trials? N-of-1 trials are for patients to appreciate what works for themselves (personalised medicine), clinical trials are to appreciate what works for others (health claims). Both can be randomised and double blind, both can be performed in a controlled environment, though this is ensured by regulation in the case of clinical trials. LTI will rank clinical trial evidence higher, all things being equal, than collections of N-of-1 trials weak evidence. The latter is OK for badges, as the likely best way at this stage to make the longevity space more test-centered. Besides, LTI will facilitate the inclusion to clinical trials as a positive gesture towards human health solutions.
  • I made short-lived mice live 50% with my super product! What badge is that?. Sorry, none: there has been too many false positives with short-lived mice, where no life extension is then seen in long-lived mice. LTI will only accept non-short lived controls (at least 820 days of median lifespan for mice and rats) and above-normal treatment lifespans (at least 920). In order to encourage innovation such as relying on shrews and to avoid cheating with specific long-live strains, LTI may rely on references like https://pmc.ncbi.nlm.nih.gov/articles/PMC2768517/table/T1/ - better contact LTI in advance for such innovations.
  • Are there conflicts of interest with the team or the advisory board? LTI takes fees on tests and not further use but various if not all team and board members are/have or will be involved in methods to assess biological ages and solutions to aging. This creates both conflicts of interest on paper and a formidable know-how for longevity progress. The board and team were selected for their genuine will over the years to deliver human longevity and the rules here above apply in any case.

Why is testing essential in the longevity space?

  • Testing Longevity in people takes decades and enormous sums of money. The temptation is to bypass even intermediate tests, both in research and industry. So the field requires some guidance with proxies of lifespan, starting with biological clocks in people and animal lifespan tests. A longevity industry without such tests is wind and worse, some products will later reveal to have caused cancers or other negative secondary effects.
  • We bring stakeholders together here to facilitate these tests, discover and share results. We believe the badges will expedite human longevity progress by enlightening what works and healthily questioning other approaches, while letting them mature. Let us here create an impactful longevity research and industry.

Team

Dr Edouard Debonneuil

Dr Edouard Debonneuil

Edouard is a longevity veteran (25 years); after aging research at the Pasteur Institute, UCLA and Inserm he co-founded the International Longevity Alliance and its French branch Longévité & Santé.

Edouard founded the Longevity Testing Institute to shed light on what truly works for healthier, longer lives, but also as a bridge to many lifespan tests of rodents and even shorter-lived animals, as he believes that their shorter lives is the support to rapidly identify solutions to aging in our lifetime while testing and validating how they apply to people

François Robin-Champigneul

François Robin-Champigneul

Researcher on functional biological clocks and on supercentenarians

François has developed a passion for the life of the oldest olds and their potential secrets for longevity. Interested in confronting hypotheses with measurable real effects, he developed math and data analysis to assess mortality risk (in other terms, biological age) based on blood, urine or non-invasive measurable markers of body function. François will adjust the LTI and facilitate its good use by various stakeholders towards more light on how to live longer healthier lives.

Sacha Martinelle

Sacha Martinelle

Mobilizing science and society toward very long lives

With a background spanning mathematics, economics, and public policy, Sacha has been part of the earliest community efforts in longevity and is now helping to connect scientists, entrepreneurs, and enthusiasts around the world. He aims to turn longevity from a niche pursuit into a coordinated, global effort - building infrastructures like the Longevity Testing Institute to accelerate discoveries and bring longer, healthier lives within reach for all.

Advisory Board

Dr Aubrey de Grey

Dr Aubrey de Grey

World leader of the ongoing longevity revolution movement, leads the Longevity Escape Velocity Foundation (LEVF)

Pioneer of rejuvenation research who champions ambitious strategies to repair age-related damage. Dr Aubrey de Grey would love to see a large Robust Rodent Rejuvenation project take place (mice and rats), perhaps even with a parallel on patients

Pr George Church

Pr George Church

Accepted to advise LTI because 'Testing standards are & will be quite important'. The Time magazine featured George Church as one of the 100 most influential people in the world.

George is Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and MIT. He is Director of the U.S. Department of Energy Technology Center and Director of the National Institutes of Health Center of Excellence in Genomic Science. He has received numerous awards including the 2011 Bower Award and Prize for Achievement in Science from the Franklin Institute and election to the National Academy of Sciences and Engineering.

Natalie Coles

Natalie Coles

World supercentanarian specialist

Researcher in the biology of aging, with specialist expertise in the oldest old humans - supercentenarians, who are defined as those who have reached the age of 110. Her primary activity has been to draw blood from such people and their offspring, for a wide variety of research applications.

Dr Codrin Blosiu

Dr Codrin Blosiu

Board certified and a Fellow of the American Academy of Anti-Aging Medicine and Fellow of Longevity Medicine

Doctor Codrin Blosiu serves on numerous international scientific and medical advisory boards. He is dedicated to the testing and optimization of the whole physical and mental health of his patients focusing on prevention and anti-aging rejuvenation. He notably worked with the Navy SEALs, US Olympic athletes and NASA and continues to put education and scientific research at the forefront of his profession.

Pr Ellen Segal

Pr Ellen Segal

Physiotherapist and nutritionist, specialist in cutting-edge longevity therapies

Honorary Professor of Langbustech University, New Jersey. Member of the International Longevity Alliance. Radical Life Extension Group Mitospace research group Head of Health Department AI Midas Preventive Medicine, Hyperbaric Medicine Anti-aging, Longevity therapies. She provides cutting-edge, science-based solutions by combining advanced anti-aging therapies with proactive longevity strategies.

Pr Wenbin Li

Pr Wenbin Li

Chairman of the Asia-Pacific Society of Longevity Medicine in China

Doctor Wenbin Li is a world specialist on brain cancers, he was principal investigator for more than a dozen clinical trials and believes that even hospital patients would benefit from anti-aging science, to face diseases and treatments with more resilience.

Tina Woods

Tina Woods

Social Entrepreneur and System Architect in Healthy Longevity

Tina Woods is a mission-driven social entrepreneur and system architect bringing diverse stakeholders together in shared endeavours to improve human and planetary health, working at the cross section of science, technology, investment and policy/government.